Chemistry and Biology of Nucleosides and Nucleotides is a collection of papers presented at the symposium on the Chemistry and Biology of Nucleosides and Nucleotides, held on August 30-September 1, 1976, as part of the San Francisco Centennial Meeting of the Carbohydrate Division of the American Chemical Society. Contributors explore the chemistry and biology of nucleosides and nucleotides ans well as the different chemical and instrumental techniques used in their synthesis. This book is comprised of 28 chapters and begins by describing the synthesis of a gene and its introduction into a biological system where it proved to be functional. The synthesis of nucleosides and nucleotides with anticancer and antiviral activity is also discussed, along with the rationale for the design and synthesis of such compounds. Simple models of nucleic acid interactions are described. Subsequent chapters explore the chemistry and biological activity of C-nucleosides related to pseudouridine and of some nucleoside analogs active against tumor cells; the selectivity and stereospecificity of the ribosylation reaction; synthesis of C-glycosyl thiazoles; and C-nucleoside isosteres of some nucleoside antibiotics. This monograph will serve as reference and source material for many workers in biomedical research as teaching material for instructors of advanced science courses.

lgrsnf/A:\_for_add\1\SD\9780123261403 (34).pdf

nexusstc/Chemistry and Biology of Nucleosides and Nucleotides/82006e8e907beb5424335579edd740e4.pdf

zlib/Science (General)/Robert Harmon (Eds.)/Chemistry and Biology of Nucleosides and Nucleotides_2217759.pdf

Chemistry of Nucleosides and Nucleotides (Discontinued (Chemistry of Nucleosides and Nucleotides))

L.B. Townsend, L. B. Townsend, Roland K. Robins, Leroy B. Townsend

edited by Robert E. Harmon, Roland K. Robins, Leroy B. Townsend

Chemistry and Biology of Nucleosides and Nucleotides Conference

Elsevier Science & Technology Books

Elsevier - Health Sciences Division

Morgan Kaufmann Publishers

Mosby, Incorporated

Brooks/Cole

Academic Press rapid manuscript reproduction, New York, 1978

New York ; San Francisco ; London, 1978

United States, United States of America

New York, New York State, 1978

Saint Louis, 2014

6, 2012

lg1048730

{"isbns":["0123261406","0323148271","9780123261403","9780323148276"],"last_page":472,"publisher":"Academic Press"}

Includes bibliographical references and index.
Papers presented at a symposium held in San Francisco, Aug. 30-Sept. 1, 1976.

Content:
Front Matter , Page iii
Copyright , Page iv
Dedication , Page v
List of Contributors , Pages xi-xvii
Preface , Pages xix-xxi , Robert E. Harmon
TOTAL SYNTHESIS OF A BACTERIAL GENE II: THE TOTAL DNA INCLUDING THE PROMOTER AND ITS TRANSCRIPTION , Pages 1-20 , RAMAMOORTHY BELAGAJE, EUGENE L. BROWN, HANS-JOACHIM FRITZ, MICHAEL J. GAIT, ROBERT G. LEES, KJELD NORRIS, TAKAO SEKIYA, TATSUO TAKEYA, ROLAND CONTRERAS, HANS KüPPER, MICHAEL J. RYAN, H. GOBIND KHORANA
TOTAL SYNTHESIS OF A BACTERIAL GENE I: CHEMICAL SYNTHESIS OF OLIGONUCLEOTIDES AND USE OF HIGH-PRESSURE LIQUID CHROMATOGRAPHY , Pages 21-36 , HANS-JOACHIM FRITZ, RAMAMOORTHY BELAGAJE, EUGENE L. BROWN, REBECCA H. FRITA, ROGER A. JONES, ROBERT G. LEES, H. GOBIND KHORANA
THE USE OF MICROPARTICULATE REVERSED-PHASE PACKING IN HIGH-PRESSURE LIQUID CHROMATOGRAPHY OF NUCLEOSIDES , Pages 37-53 , JOHN A. MONTGOMERY, H. JEANETTE THOMAS, ROBERT D. ELLIOTT, ANITA T. SHORTNACY
CHEMICAL AND ENZYMATIC METHODS IN THE SYNTHESIS OF MODIFIED POLYNUCLEOTIDES , Pages 55-68 , THOMAS J. BARDOS, YAU-KWAN HO
SIMPLE MODELS OF NUCLEIC ACID INTERACTIONS , Pages 69-84 , J. ZEMLICKA, M. MURATA, J. OWENS
SYNTHESIS OF NUCLEOTIDES WHICH INACTIVATE ENZYMES UTILIZING ADENINE NUCLEOTIDES , Pages 85-95 , ALEXANDER HAMPTON
SYNTHESIS, ANTIVIRAL ACTIVITY, AND MECHANISM OF ACTION OF A NOVEL SERIES OF PYRIMIDINE NUCLEOSIDE ANALOGS , Pages 97-107 , WILLIAM H. PRUSOFF, TAI-SHUN LIN, MING-SHEN CHEN, GEORGE T. SHIAU, DAVID C. WARD
THE CHEMISTRY AND BIOLOGICAL ACTIVITY OF C-NUCLEOSIDES RELATED TO PSEUDOURIDINE , Pages 109-120 , DEAN S. WISE, ROBERT A. EARL, LEROY B. TOWNSEND
THE CHEMISTRY AND BIOLOGICAL ACTIVITY OF CERTAIN 4-SUBSTITUTED AND 3,4-DISUBSTITUTED PYRAZOLO (3,4-d)PYRIMIDINE NUCLEOSIDES , Pages 121-134 , RAYMOND P. PANZICA, GANAPATI A. BHAT, ROBERT A. EARL, JEAN-LOUIS G. MONTERO, LINDA W. ROTI ROTI, LEROY B. TOWNSEND
THE CHEMISTRY AND BIOLOGY OF SOME NEW NUCLEOSIDE ANALOGS ACTIVE AGAINST TUMOR CELLS , Pages 135-148 , MIROSLAV BOBEK, ALEXANDER BLOCH
POTENTIATION OF THE CHEMOTHERAPEUTIC ACTION OF ANTINEOPLASTIC AGENTS BY NUCLEOSIDES , Pages 149-158 , H. OSSWALD
COFORMYCIN AND DEOXYCOFORMYCIN: TIGHT-BINDING INHIBITORS OF ADENOXINE DEAMINASE , Pages 159-197 , R.P. AGARWAL, SUNGMAN CHA, G.W. CRABTREE, R.E. PARKS Jr.
SYNTHESIS AND CHEMISTRY OF A NEW ANTIVIRAL-ANTIBIOTIC NUCLEOSIDE IN THE ANHYDRO FORM: APPLICATION OF A NOVEL 1,3-ELECTROPHILIC (C-N-C) ANNULATION REAGENT , Pages 199-210 , WENDELL WIERENGA, JOHN A. WOLTERSOM
SYNTHESIS OF 1-(2-DEOXY-β-D-Ribofuranosyl)-5,6-DIHYDRO-5-METHYL-S-TRIAZIN-2,4 (1H,3H) Dione , Pages 211-227 , H.I. SKULNICK
AN APPROACH TO THE SYNTHESIS OF 1, 9-DIRIBOSYL PURINE , Pages 229-237 , BERNARD RAYNER, CLAUDE TAPIERO, JEAN-LOUIS IMBACH
AN INITIAL STUDY ON THE SELECTIVITY AND STEREOSPECIFICITY OF THE RIBOSYLATION REACTION , Pages 239-250 , JEAN-LOUIS BARASCUT, JEAN-LOUIS IMBACH
ON THE MECHANISM OF NUCLEOSIDE SYNTHESIS , Pages 251-265 , HELMUT F. VORBRÜGGEN, ULRICH NIEDBALLA, KONRAD KROLIKIEWICZ, BÄRBEL BENNUA, GERHARD HÖFLE
SYNTHESIS AND CHEMISTRY OF CERTAIN AZOLE NUCLEOSIDES , Pages 267-286 , JOSEPH T. WITKOWSKI, ROLAND K. ROBINS
THE SYNTHESIS OF HETEROCYCLIC ANALOGS OF PURINE NUCLEOSIDES AND NUCLEOTIDES CONTAINING A BRIDGEHEAD NITROGEN ATOM , Pages 287-299 , GANAPATHI R. REVANKAR, ROLAND K. ROBINS
DETERMINATION OF THE SITE OF GLYCOSYLATION IN VARIOUS NUCLEOSIDES BY CARBON-13 NMR SPECTROSCOPY , Pages 301-310 , PHOEBE DEA, ROLAND K. ROBINS
A “GEOMETRY-ONLY“ 1 H NMR METHOD FOR DETERMINATION OF THE ANOMERIC CONFIGURATION OF RIBOFURANOSYL COMPOUNDS , Pages 311-328 , MORRIS J. ROBINS, MALCOLM MACCOSS
INVESTIGATION OF NUCLEOSIDE ALKYLPHOSPHONATES , Pages 329-346 , M.N. PREOBRAZHENSKAYA, S.YA. MELNIK, T.P. NEDOREZOVA, I.D. SHINGAROVA, D.M. OLEINIK
THE TERT -BUTYLDIMETHYLSILYL GROUP AS A PROTECTING GROUP IN OLIGONUCLEOTIDE SYNTHESIS , Pages 347-358 , WILFRIED KÖHLER, WILHELM SCHLOSSER, GEETA CHARUBALA, WOLFGANG PFLEIDERER
ADVANCES IN THE SYNTHESIS OF C -GLYCOSYL NUCLEOSIDES , Pages 359-380 , JOHN G. MOFFATT, HANS P. ALBRECHT, GORDON H. JONES, DAVID B. REPKE, GÜNTER TRUMMLITZ, HIROSHI OHRUI, CHHITAR M. GUPTA
SYNTHESIS OF C-GLYCOSYL THIAZOLES , Pages 381-386 , M. FUERTES, M.T. GARCÍA-LÓPEZ, G. GARCÍA-MUÑOZ, M. STUD
A NEW METHOD FOR THE SYNTHESIS OF 2′-DEOXY-2′-SUBSTITUTED PURINE NUCLEOSIDES. SYNTHESIS OF THE ANTIBIOTIC 2′-DEOXY-2′-AMINOGUANOSINE , Pages 387-396 , MORIO IKEHARA, TOKUMI MARUYAMA, HIROKO MIKI
SYNTHESIS AND REACTION OF NUCLEOSIDES CONTAINING SULFUR FUNCTIONS IN THE SUGAR PORTION , Pages 397-414 , TOHRU UEDA, AKIRA MATSUDA, TAMOTSU ASANO, HIDEO INOUE
NEW C-NUCLEOSIDE ISOSTERES OF SOME NUCLEOSIDE ANTIBIOTICS , Pages 415-439 , JACK J. FOX, KYOICHI A. WATANABE, ROBERT S. KLEIN, CHUNG K. CHU, STEVE Y-K. TAM, URI REICHMAN, KOSAKU HIROTA, J.-S. HWANG, FEDERICO G. DE LAS HERAS, IRIS WEMPEN
Index , Pages 441-468

2013-11-27